The input masks can have any grid or axis ordering, and may cover a single monomer or the whole multimer.
Once a person is diagnosed with VWD, further testing such as vWF multimer analysis and ristocetin-induced platelet aggregation (RIPA) should be performed to determine the subtype.
Multimer analysis evaluates the structure of the vWF, and RIPA measures how much ristocetin is required to cause the clumping of platelets in a blood sample.
The vWF multimer analysis is able to differentiate children with a structurally normal vWF (Type 1) from children with a structurally abnormal vWF (Type 2) and is often able to identify the subtype of patients with Type 2 VWD.
RIPA is usually absent and the multimer analysis shows undetectable vWF in children with type 3 VWD.