(genetics) A non-random association of two or more alleles at two or more loci; normally caused by an interaction between genes, and often illustrated on a pairwise linkage disequilibrium diagram (HapMap)
Linkage-disequilibrium Sentence Examples
Model-based linkage disequilibrium unit (LDU) maps appear robust to marker density and consistently influenced by marker allele frequency.
We examined linkage disequilibrium between all pairs of biallelic loci, Lewontin's D ' and r2.
The three polymorphisms studied were found to be in strong linkage disequilibrium.
Nat Genet 29, 229-232, PubMed 46 Kruglyak, L. (1999) Prospects for whole-genome linkage disequilibrium mapping of common disease genes.
REFERENCES Johnson, T. (2005) Multipoint linkage disequilibrium mapping using multilocus allele frequency data.