If mononucleosis is suspected, a physician will typically conduct a physical examination, including a "Monospot" antibody blood test that can indicate the presence of proteins or antibodies produced in response to infection with the EBV.
Epstein-Barr virus (EBV), for example, is associated with lymphoma, the hepatitis viruses are associated with liver cancer, HIV is associated with Kaposi's sarcoma, and the bacteria Helicobacter pylori is associated with stomach cancer.
As with Kawasaki disease, various infectious organisms have been proposed as the cause of IPAN, including hepatitis B virus, Epstein-Barr virus (EBV), various retroviruses, streptococci, and even a virus usually found in cats.
While antibiotics do not affect EBV, the sore throat accompanying mononucleosis can be complicated by a streptococcal infection, which can be treated with antibiotics.
In children, ITP is usually triggered by a virus infection, most often rubella, chickenpox, measles, cytomegalovirus (CMV), or Epstein-Barr virus (EBV).