It was the scene of the first banishment of St Athanasius in 336.
Leading examples may be found in the various prosecutions of St Athanasius, in whose case also there is the germ of an appeal, tanquam ab abusu.
The trial of St Athanasius led to extensions of the right of appeal.
A synod was held at Rome, attended by bishops from various regions, which reversed the original judgment of the synod of Tyre which had condemned Athanasius.
A few years later, in 347, the council of Sardica, a council of practically the whole West save Africa, reversed Tyre and acquitted St Athanasius after a full judicial inquiry.