The classical example is the case of Paul of Samosata, bishop of Antioch.
After some previous abortive trials, Paul of Samosata was deposed and excommunicated, in 269, by a great synod of the Antiochene district.
After running south-east through the grandest scenery, and closely approaching the source of the western Tigris, it turns south-west and leaves the mountains a few miles above Samsat (Samosata; altitude, 1500 ft.).
Samsat itself represents the ancient Samosata, the capital of the Seleucid kings of Commagene (Kuinukh of the Assyrian inscriptions), and here the Persian Royal Road from Sardis to Susa is supposed to have crossed the river.
Here they are in line with non-Christian writers or culture-mockers like Lucian of Samosata; or graver spirits like Porphyry, who champions Neo-Platonism as a rival to Christianity, and does pioneer work in criticism by attacks on some of the Old Testament books.