Along with the exuded serum this fills up the breach in the tissues and the whole is rapidly formed into a fibrinous mass due to the disintegration of the polymorphonuclear leucocytes setting free their ferment.
The addition of some of the liquid squeezed out from a blood-clot, of the squeezed blood-clot itself, or of a little blood-serum, is sufficient to throw down a fibrinous coagulum (Buchanan), evidently by these substances supplying the fibrin-ferment.
(Many such changes are usually grouped together under the heading of " inflammation " of varying degree--acute, subacute and chronic.) Degeneration and death of cells, haemorrhages, serous and fibrinous exudations, leucocyte emigration, proliferation of connective tissue and other cells, may be mentioned as some of the fundamental changes.
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