When you walk into a room that is absolutely filthy and dirty, this is an example of when you might say "ugh."
When I saw how the stuff in the larder had gone moldy all I could think of to say was, "Ugh"
Ugh, how hard it is!
"Ugh," Jessi replied with a grimace.
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"Ugh. Fine," Ashley said with an exasperated sigh.
"Ugh. The hussars will get it hot!" said Nesvitski; "they are within grapeshot range now."