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At the top of each of these pouches there is a minute orifice, the aperture of a small tubule lying above each pouch in the dorsal coelom.
The segment that drains glomerular filtrate from the Bowman's capsule is the proximal convoluted tubule.
Experimental work shows that losartan (tho not its active metabolite) competitively inhibits urate reabsorption in the renal proximal tubule.
These crystals are comparatively soluble but nevertheless block the tubule.
These small molecules pass through the renal tube (coiled tubule) which is surrounded by a capillary network.