Screw-up Definition

skro͝oup
screwup, screwups, screw-ups
noun
A serious mistake; blunder; mess.
Webster's New World
A person who screws up.
Webster's New World
The definition of a screw up is a mistake or something that has been done in error.
An example of a screw-up is a streaky, messy, blotchy paint job that has to be totally redone.
YourDictionary

(colloquial) A substantial mistake, usually causing problems for more people than just the person or group who made it.

Wiktionary
(colloquial) A person who often makes substantial mistakes.
Wiktionary
Synonyms:
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verb
To screw up is to make a mistake or error.
An example of screw up is when you add 2+2 and accidentally come up with 5.
YourDictionary
Antonyms:

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screw-up