Regardless of the specific cause of DIC, the results are a malfunction of thrombin (an enzyme) and prothrombin (a glycoprotein), which activate the fibrinolytic system, releasing clotting factors in the blood.
Hypothrombinemia is diagnosed based on family history and the use of tests that measure vitamin K deficiency, deficiency of prothrombin, and measurements of clotting factors V, VII, IX, and X.
A deficiency of factor VII, also called serum prothrombin conversion accelerator (SPCA) deficiency, affects one in 500,000 people and is often diagnosed in newborns.
Diagnosis usually requires a number of laboratory tests that measure concentrations of platelets and fibrinogen in the blood along with measuring prothrombin time.
Factor XI deficiency is determined by measuring the specific coagulation factor as well as other coagulation tests including prothrombin time and clotting time.