Anyone who has a primary immunodeficiency is going to face problems.
Parker. The Official Parent's Sourcebook on Primary Immunodeficiency.
Hyper-IgM syndrome is a primary immunodeficiency disorder in which the child's body fails to produce certain specific types of antibodies.
Children with XHIM are more likely to develop enlarged lymph nodes than children with other primary immunodeficiency disorders.
Other family members have been diagnosed with a primary immunodeficiency disorder.