inorganic borate pretreated roof tile battens, fascias etc may be available in certain parts of the country.
Most are already pretreated, but you should apply a leather protector of your own as well - or the shop will do it for you.
Small stains can be pretreated immediately when you are away from home with portable spot removers such as Shout Wipes or Tide Stain Removal Pen.
Some condoms and lube are pretreated with spermicide.
Though the tote is pretreated, it's inevitable that it will require some maintenance through natural wear.