A spineless, dome-shaped cactus (Lophophora williamsii) native to Mexico and the southwest United States, having buttonlike tubercles that contain the hallucinogen mescaline and are traditionally used in rituals by certain Native American peoples.
A small, spineless cactus (Lophophora williamsii) found from southwest United States to central Mexico that produces buttonlike tubercles that can be chewed for its psychedelic effect, primarily from the drug mescaline.
A mescal button produced by the plant.
Origin of peyote
American Spanish from Nahuatl peyotlcaterpillar cocoon, peyote (because the tufts of woolly hair in the center of its tubercles resemble caterpillar cocoons)
American Heritage Dictionary of the English Language, 5th Edition