The use of methotrexate high-dose regimens recommended for osteosarcoma requires meticulous care due to the potential for additive or synergistic renal toxicity.
These results strongly suggest that Rb gene alteration is pertinent to the tumorigenesis of most osteosarcoma cases and some other bone and soft-tissue tumors.
Children with osteosarcoma (bone cancer) and other solid tumors are candidates for surgery, however.