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The use of methotrexate high-dose regimens recommended for osteosarcoma requires meticulous care due to the potential for additive or synergistic renal toxicity.
These results strongly suggest that Rb gene alteration is pertinent to the tumorigenesis of most osteosarcoma cases and some other bone and soft-tissue tumors.
Children with osteosarcoma (bone cancer) and other solid tumors are candidates for surgery, however.
Osteogenic sarcoma, or osteosarcoma, is the most common form of bone cancer, accounts for 6 percent of all instances of the disease, and for about 5 percent of all cancers that occur in children.
Nine hundred new cases of osteosarcoma are diagnosed in the United States every year.