The helper virus envelope glycoprotein affects the disease specificity of a recombinant murine leukemia virus carrying a v- myc oncogene.
Oncogene inactivation uses the same techniques employed for dominantly inherited monogenic diseases.
A change in the DNA causes a special gene called an oncogene to be switched on.
No single activated oncogene can be detected in a transformation assay.
Investigation showed the retroviral vector used to load a gene into bone marrow cells had inadvertently carried its DNA into a known oncogene.