Methotrexate definition

mĕthə-trĕksāt
A toxic antimetabolite, C20 H22 N8 O5 , that acts as a folic acid antagonist to interfere with cellular reproduction and is used to treat psoriasis, certain cancers, and some inflammatory diseases such as rheumatoid arthritis.
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An orange-brown, crystalline powder, C20H22N8O5, that is a folic acid antagonist: used in medicine, esp. in treating leukemia, various tumors, psoriasis, and rheumatoid arthritis.
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A folate antagonist, C20 H22 N8 O5 , that inhibits DNA synthesis and is used to treat psoriasis, certain cancers, and some inflammatory diseases such as rheumatoid arthritis. It is sometimes used in combination with misoprostol to induce abortion in early pregnancy.
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A toxic drug that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases, such as rheumatoid arthritis. Chemical formula: C20H22N8O5.
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(medicine) An antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases.
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Origin of methotrexate

  • methotre- (probably shortening and alteration of methylaminopterin one of its chemical names) (methyl) (aminopterin) perhaps (o)x(y)– –ate

    From American Heritage Dictionary of the English Language, 5th Edition

Methotrexate Sentence Examples

  • Methotrexate affects spermatogenesis and oogenesis during the period of its administration which may result in decreased fertility.

  • Individuals taking Methotrexate should avoid folic acid in doses of 1mg and above unless under supervision.

  • Intra-arterial infusions of methotrexate have been used in the treatment of head and neck cancers.

  • Probenecid can severely inhibit renal excretion of methotrexate, and so is contraindicated.

  • There is research going on into injecting the chemotherapy drug methotrexate directly into the eyeball to treat lymphoma of the eye.

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Words near methotrexate in the Dictionary