In the melanomas, staining was relatively uniform, while in primary acquired melanosis there was cell-to-cell variability in the staining.
Our own studies in London suggest that intracranial melanosis is relatively rare.
We found evidence of intracranial or intraspinal melanosis in around 1 in 14 of these children.
Primary acquired melanosis may lead to the development of melanoma even in blacks.
In chronic cases the eventual effects are anaemia, melanosis, enlargement of the spleen and liver, and general cachexia.