Levels between 20 and 30 mg/dL associated with prematurity and hemolytic disease may increase the risk of kernicterus.
Kernicterus is still relatively uncommon but has been on the rise with the mandated early postnatal discharge policies.
In the past Rhesus (Rh) blood factor incompatibility between the mother and child was a major cause of kernicterus.
Blackmon, Lillian R., et al. "Research on Prevention of Bilirubin-Induced Brain Injury and Kernicterus: National Institute of Child Health and Human Development Conference Executive Summary."
Kernicterus: also called Rh incompatibility, a condition that develops when there is a difference in Rh blood type between that of the mother (Rh negative) and that of the fetus (Rh positive).