The drug is obviously contraindicated in pregnancy and when haemorrhoids are already present.
Zyban is contraindicated for use in patients with severe hepatic cirrhosis.
This drug is also contraindicated in women who are pregnant or breast-feeding an infant.
Choice of Drug Unless contraindicated (e.g. jaundice or known hypersensitivity ), rifampicin is the drug of choice for meningococcal chemoprophylaxis.
It is relatively contraindicated in asthma and renal failure and should be given in small increments in uncorrected hypovolaemia.