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The disease gene is named CFTR, which stands for cystic fibrosis transmembrane conductance regulator.
What is the peak conductance of the potassium conductance?
Molecules are able to activate chloride conductance in airway cell line, primary human cell cultures and most importantly from cells with CFTR mutations.
Binding of GABA opens an integral chloride channel, producing an increase in membrane conductance that results in inhibition of neuronal activity.
There has also been the suggestion that benzodiazepines can increase the conductance of high affinity GABA A receptors 79.
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