The congenital immunodeficiency disorder, Bruton's agammaglobulinemia, also known as X-linked agammaglobulinemia, results in a decrease or absence of B lymphocytes and, therefore, a decreased ability to make antibodies.
If a mother is a carrier for an X-linked recessive form of EDS, she may have affected or unaffected sons, or carrier or unaffected daughters, depending on the second sex chromosome inherited from the father.
Unlike the other MPS conditions, MPS II is inherited in an X-linked recessive manner, which means that the gene causing the condition is located on the X chromosome, one of the two sex chromosomes.
X-linked hypogammaglobulinemia can occur in combination with growth hormone (GH) deficiency, producing short stature and delayed puberty, primarily in boys but also occurring in girls.
X-linked adrenoleukodystrophy (X-ALD), a sex-linked disorder characterized by progressive symptoms that begin as behavioral changes, muscle weakness, and speech difficulties.