telomerase Hear it!

telomerase Definition

telo·mer·ase (te lämə rāz′, -rās′)

noun

an enzyme found in cancer cells that protects or repairs the cells' telomeres, allowing the cells to reproduce indefinitely: used in medical research to extend the life of noncancerous cells

Etymology: telomere + -ase

telomerase Usage Examples

Converse of object

  • call: He said: For a number of years we have been studying a molecule called telomerase, which is present in cancer cells.
  • express: It is thought that some cancer cells become " immortalized " because they express telomerase and can therefore continue to proliferate indefinitely.
  • activate: In a second study, a Danish team found that permanently activating telomerase in similar stem cells also made them cancerous.

Preposition: in

  • cell: To the authors ' knowledge, the role of telomerase in germ cell derived malignancies has not previously been evaluated.

Adjective modifier

  • human: They suggest that SCLC would be a prime target for therapies directed at the RNA component of human telomerase.

Modifies a noun

  • inhibitor: The enzyme is found in most types of tumor cells but not in healthy cells, indicating the potential of telomerase inhibitors in chemotherapy.
  • promoter: Conclusions These results indicate that the telomerase promoters have the capacity to drive the expression of the NAT.
  • enzyme: However, the telomerase enzyme can build the telomeres up again, extending the life of the cell.
  • activity: A matter of great relevance, however, is the presence of telomerase activity in most tumors.
  • expression: A number of studies suggest that telomerase expression is an adverse prognostic factor for lung cancers.
  • assay: Two cases of breast carcinoma and two cases of ovarian carcinoma were also included as positive controls in the telomerase assay.

Noun used with modifier

  • enzyme: The majority of human tumors stabilize their telomere lengths by activation of the enzyme telomerase.
  • mouse: However, both the human and mouse telomerase RNA genes are within CpG islands and may therefore be under the regulation of DNA methylation.
  • anti-: Is small cell lung cancer the perfect target for anti- telomerase treatment?

Browse dictionary entries near telomerase

  1. telome
  2. telodynamic
  3. telo-
  4. Telnet
  5. telly
  6. Tellus
  7. tellurous acid
  8. tellurous
  9. tellurize
  10. tellurium
  1. telomere
  2. telophase
  3. telos
  4. telpher
  5. telpherage
  6. telson
  7. Telstar
  8. Telugu
  9. temblor
  10. temerarious