Origin: It Sistino < Sisto (< ML Sixtus, for L Sextus, lit., sixth)
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- Of or relating to any of the five popes named Sixtus, especially Sixtus IV (1414-1484; reigned 1471-1484) and Sixtus V (1520-1590; reigned 1585-1590).
- Of or relating to the Sistine Chapel in the Vatican.
Origin: Italian sistino, from New Latin sixtīnus, from Medieval Latin Sixtus, the name of several popes, from Latin Sextus, Roman praenomen, from sextus, sixth; see Sext .