penetrance Definition
pen·etrance (pen′i trəns)
noun
Genetics the degree of regularity with which a gene produces its specific effect in its carriers in a population
Etymology: < penetr(ate) + -ance
penetrance Usage Examples
Preposition: of
- mutation: However, the penetrance of the major haemochromatosis mutations is not accurately known.
- gene: The penetrance of the disease gene is ~ 75 % .
- genotype: The etiology of both conditions could be further complicated by variable penetrance of the various genotypes and the involvement of environmental factors.
- haemochromatosis: News Stories Very low penetrance of hereditary haemochromatosis Low mortality from untreated haemochromatosis?
Converse of object
- have: Whether the cat is heterozygous or homozygous for W, the blue eyes and deafness have incomplete penetrance.
- show: AB - PURPOSE: To identify the mutation in the RB1 gene in a Syrian family showing incomplete penetrance of retinoblastoma ( RB ).
- decrease: However, decreased penetrance of a particular gene defect cannot be excluded.
Adjective modifier
- incomplete: Incomplete penetrance refers to absence of disease despite presence of the dominant disease gene.
- reduced: There is a 50 per cent chance of parents passing on the gene, although with reduced penetrance.
- variable: A better understanding of the factors that underlie variable penetrance in mutation carriers is needed to augment our ability to counsel individual women.
- low: Last November, the HFEA launched a public debate on testing embryos for ' lower penetrance ' , late onset genetic disorders.
- high: All these conditions are ' high penetrance ' - meaning that people who have the gene are extremely likely to develop the condition.
- Very: News Stories Very low penetrance of hereditary haemochromatosis Low mortality from untreated haemochromatosis?
Modifies a noun
- gene: Where there are known rare, high penetrance susceptibility genes ( e.g.
- susceptibility: Where there are known rare, high penetrance susceptibility genes ( e.g.
- estimate: Therefore, penetrance estimates will tend to be inflated.
Browse dictionary entries near penetrance
- ‹ penetralia
- ‹ penetrable
- ‹ penes
- ‹ peneplain
- ‹ Penelope
- ‹ Penecuik, DrAlex
- ‹ pendulum
- ‹ pendulous
- ‹ pendragon
- ‹ pending
- penetrant ›
- penetrate ›
- penetrating ›
- penetration ›
- Penetration Testing ›
- penetrometer ›
- Peneus ›
- Penfield,Wilder Graves ›
- penguin ›
- penholder ›

