Shortly after the accession of Cyril to the patriarchate of Alexandria in 412, owing to her intimacy with Orestes, the pagan prefect of the city, Hypatia was barbarously murdered by the Nitrian monks and the fanatical Christian mob (March 415).
A favourable pretext for gratifying their revenge was discovered in the shelter which Chrysostom had given to four Nitrian monks, known as the tall brothers, who had come to Constantinople on being excommunicated by their bishop, Theophilus of Alexandria, a man who had long circulated in the East the charge of Origenism against Chrysostom.
14,451, which was brought in 1842 from the monastery of St Mary in the Nitrian desert, and was edited by Cureton in 1858; and three leaves in Berlin (MS. Orient.
From Palestine Jerome and his companions went to Egypt, remaining some time in Alexandria, and they visited the convents of the Nitrian desert.
Another of the intimates of Rufinus was John, bishop of Jerusalem, and formerly a Nitrian monk, by whom he was ordained to the priesthood in 39 0.