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methotrexate Definition

metho·trex·ate (met̸h′ō treksāt′)

noun

an orange-brown, crystalline powder, CHNO, that is a folic acid antagonist: used in medicine, esp. in treating leukemia, various tumors, psoriasis, and rheumatoid arthritis

Etymology: meth(yl) + -trex- (< ?) + -ate

methotrexate Usage Examples

Converse of object

  • receive: Patients with a known allergic hypersensitivity to methotrexate or any of the excipients should not receive methotrexate.
  • call: It is a little similar to another drug in regular use called methotrexate.
  • take: Your child should take methotrexate on the same day each week.
  • include: Review concluding that these drugs should be reserved for patients unresponsive to at least two other disease modifying drugs, including methotrexate.
  • give: Having given methotrexate what I believed more than a fair chance, I declined.
  • use: It's nice to hear about other people using methotrexate.

Preposition: in

  • patient: Reduce dose of methotrexate in patients with renal impairment.

Adjective modifier

  • subcutaneous: This prompted us to explore the use of subcutaneous methotrexate.
  • oral: NPSA ( 2004 ), Toward the safer use of oral methotrexate, Patient Safety Alert, National Patient Safety Agency, London.
  • low: Low dose methotrexate in children with juvenile rheumatoid arthritis: results of a post-trial, long-term follow up program.
  • intrathecal: After treatment with both radiation to the head and neck and intrathecal methotrexate the patient achieved complete symptom resolution.

Modifies a noun

  • nausea: Good luck xxx Reply post: Methotrexate nausea - Relief?
  • therapy: The long term side effects of methotrexate therapy on the liver in patients with juvenile rheumatoid arthritis.
  • guideline: The NPSAâs subsequent alert, Improving compliance with oral methotrexate guidelines ( patient safety alert 13 ) is published today.
  • monotherapy: Significant advantages for Enbrel in combination with methotrexate compared with Enbrel monotherapy and methotrexate monotherapy were also observed after 24 months.
  • dose: Oral methotrexate doses may be changed weekly according to your child's blood count.
  • treatment: Preliminary report of higher dose methotrexate treatment in juvenile rheumatoid arthritis.

Noun used with modifier

  • high-dose: Chronic leucoencephalopathy has also been reported in patients who received repeated doses of high-dose methotrexate with leucovorin rescue even without cranial irradiation.
  • dose: Women treated with single dose methotrexate were more likely to fail medical management of ectopic pregnancy than those treated with multiple doses.
  • drug: There is research going on into injecting the chemotherapy drug methotrexate directly into the eyeball to treat lymphoma of the eye.