an orange-brown, crystalline powder, CHNO, that is a folic acid antagonist: used in medicine, esp. in treating leukemia, various tumors, psoriasis, and rheumatoid arthritis
Origin of methotrexatemeth(yl) + -trex- (; from uncertain or unknown; perhaps ) + -ate
A toxic antimetabolite, C20H22N8O5, that acts as a folic acid antagonist to interfere with cellular reproduction and is used to treat psoriasis, certain cancers, and some inflammatory diseases such as rheumatoid arthritis.
Origin of methotrexatemethotre- (probably shortening and alteration of methylaminopterin, one of its chemical names : methyl + aminopterin) + perhaps (o)x(y)– + –ate2.