an orange-brown, crystalline powder, CHNO, that is a folic acid antagonist: used in medicine, esp. in treating leukemia, various tumors, psoriasis, and rheumatoid arthritis
Origin of methotrexatefrom meth(yl) + -trex- ( from uncertain or unknown; perhaps ) + -ate
A folate antagonist, C20H22N8O5, that inhibits DNA synthesis and is used to treat psoriasis, certain cancers, and some inflammatory diseases such as rheumatoid arthritis. It is sometimes used in combination with misoprostol to induce abortion in early pregnancy.
Origin of methotrexatemethotre- ( probably shortening and alteration of methylaminopterin one of its chemical names ) ( methyl ) ( aminopterin )perhaps (o)x(y)- -ate 2