methotrexate
methotrexate
Definition
metho·trex·ate (met̸h′ō treks′āt′)
noun
an orange-brown, crystalline powder, CHNO, that is a folic acid antagonist: used in medicine, esp. in treating leukemia, various tumors, psoriasis, and rheumatoid arthritis
Etymology: meth(yl) + -trex- (< ?) + -ate
methotrexate
Usage Examples
Converse of object
- receive: Patients with a known allergic hypersensitivity to methotrexate or any of the excipients should not receive methotrexate.
- call: It is a little similar to another drug in regular use called methotrexate.
- take: Your child should take methotrexate on the same day each week.
- include: Review concluding that these drugs should be reserved for patients unresponsive to at least two other disease modifying drugs, including methotrexate.
- give: Having given methotrexate what I believed more than a fair chance, I declined.
- use: It's nice to hear about other people using methotrexate.
Preposition: in
- patient: Reduce dose of methotrexate in patients with renal impairment.
Adjective modifier
- subcutaneous: This prompted us to explore the use of subcutaneous methotrexate.
- oral: NPSA ( 2004 ), Toward the safer use of oral methotrexate, Patient Safety Alert, National Patient Safety Agency, London.
- low: Low dose methotrexate in children with juvenile rheumatoid arthritis: results of a post-trial, long-term follow up program.
- intrathecal: After treatment with both radiation to the head and neck and intrathecal methotrexate the patient achieved complete symptom resolution.
Modifies a noun
- nausea: Good luck xxx Reply post: Methotrexate nausea - Relief?
- therapy: The long term side effects of methotrexate therapy on the liver in patients with juvenile rheumatoid arthritis.
- guideline: The NPSAâs subsequent alert, Improving compliance with oral methotrexate guidelines ( patient safety alert 13 ) is published today.
- monotherapy: Significant advantages for Enbrel in combination with methotrexate compared with Enbrel monotherapy and methotrexate monotherapy were also observed after 24 months.
- dose: Oral methotrexate doses may be changed weekly according to your child's blood count.
- treatment: Preliminary report of higher dose methotrexate treatment in juvenile rheumatoid arthritis.
Noun used with modifier
- high-dose: Chronic leucoencephalopathy has also been reported in patients who received repeated doses of high-dose methotrexate with leucovorin rescue even without cranial irradiation.
- dose: Women treated with single dose methotrexate were more likely to fail medical management of ectopic pregnancy than those treated with multiple doses.
- drug: There is research going on into injecting the chemotherapy drug methotrexate directly into the eyeball to treat lymphoma of the eye.
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