- A city on the Dnieper in Ukraine, administrative centre of Dnipropetrovsk province (oblast).
- Khmelnytskyi province (oblast), in south-eastern Ukraine.
- Bohdan Khmelnytsky (c. 1595–1657), a Ukrainian Cossack hetman who led an uprising against the Polish-Lithuanian Commonwealth and signed the Treaty of Pereyaslav with Czar Alexis I of Russia.
From Ukrainian Хмельницький (Xmelʹnýcʹkyj), after the Ukrainian Cossack Bohdan Khmelnytsky. Derived from хміль (xmil’, “hops, humulus”).