Politically he was a pupil of Alexis Bestuzhev; consequently, when in the middle 'fifties Russia suddenly turned Francophil instead of Francophobe, Panin's position became extremely difficult.
But in 1185, during his absence from the capital, his lieutenant ordered the arrest and execution of Isaac Angelus, a descendant of the first Alexis.
The celebrated " homo sum " is a translation from Alexis, and the spirit of it breathes in many passages of the Greek drama.
He negotiated with Alexis Comnenus at Constantinople, re-established at Nicaea some discipline among the crusaders, caused the siege of Antioch to be raised and died in that city of the plague on the 1st of August 1098.
Here, too, he died, attended by his physician, Dr Majendie, and his mathematical coadjutor, Alexis Bouvard., on the 5th of March 1827.
