Toll-like receptorToll-like receptor
Any of a class of proteins that are located within membranes, often on the cell surface, and are an important part of the innate immune system. Toll-like receptors recognize and bind to pathogens or to fragments resulting from cell damage and then activate biochemical pathways that generate an immune response.
Origin of Toll-like receptorFrom Toll the name of a gene in drosophila fruit flies that when mutated affects embryonic development and the innate immune system from German toll amazing, great, cool ( in Das is ja toll! That's really cool!, exclamation of German biologist Christiane Nüsslein-Volhard upon observing in 1985 that mutations in a particular gene caused ventral underdevelopment in drosophila, a discovery that eventually led to the identification of Toll-like receptors ) from Middle High German tol foolish, crazy, good-looking from Old High German foolish Old English dol dull from Germanic dula- dumbfounded, stupefied