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tamoxifen Definition

ta·moxi·fen (tə mäksə fen′)

noun

a synthetic hormone, CHNO, used as an estrogen-blocking drug to inhibit the growth of certain types of tumors, esp. in cases of advanced breast cancer: in full tamoxifen citrate

tamoxifen Usage Examples

Converse of object

  • take: In most women the benefits of taking tamoxifen outweigh the risks.
  • receive: The main finding was a 49 % reduction in the incidence of breast cancer among the participants who were randomly assigned to receive tamoxifen.
  • use: The risk is small compared to the benefits of using tamoxifen to treat breast cancer.
  • compare: Review This review sought information on all trials in early breast cancer begun before 1990 comparing adjuvant tamoxifen versus no such treatment.
  • show: Tamoxifen A randomized controlled trial has shown that tamoxifen reduces the risk of developing breast cancer in women at increased risk for the disease.
  • give: They were either given 20 mg tamoxifen daily for five years or a placebo.

Preposition: for

  • cancer: Tamoxifen for early breast cancer: an overview of the randomized trials.
  • prevention: There are other ongoing randomized trials in Europe testing the efficacy of tamoxifen for the primary prevention of breast cancer.
  • woman: There have been a few studies of tamoxifen for women who have advanced ovarian cancer that hasn't responded to chemotherapy treatment.

Adjective modifier

adjuvant: Randomized trial of two versus five years of adjuvant tamoxifen for post-menopausal early stage breast cancer.

Modifies a noun

  • therapy: These appear to persist despite four years of tamoxifen therapy and increase prior to relapse in some patients.
  • treatment: The included trials were conducted in women with metastatic breast cancer after the failure of the tamoxifen treatment.
  • citrate: Tamoxifen citrate is the only approved chemopreventive agent for breast cancer.
  • trial: McDonald CC, Stewart HJ: Fatal myocardial infarction in the Scottish adjuvant tamoxifen trial.

Noun used with modifier

  • drug: The thought came to mind after we looked at the success of the drug tamoxifen in fighting - and preventing - breast cancer.
  • term: Q: Regarding the therapeutic effects of estrogens, more more women these days are on long term tamoxifen for breast cancer.
  • treatment: Hormone treatment Doctors have been looking at the hormone treatment tamoxifen to treat advanced ovarian cancer.

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