Sentence Examples


  • When a second mutation occurs, the cell that contains the mutation no longer has any normal copy of the tumor suppressor gene.
  • An RB1 gene is non-functional when it is changed or missing (deleted) and no longer produces normal tumor suppressor protein.
  • RB1 produces a tumor suppressor protein that normally helps to regulate the cell cycle of cells such as those of the retina.
  • Normally, the tumor suppressor protein produced by RB1 prevents a retinal cell from becoming cancerous.
  • PYGM is one of a group of genes known as tumor suppressor genes that help to control cell division.