The most common telltale symptom, however, is PCP; in fact, the frequency of Pneumocystis carinii pneumonia in children with hyper-IgM syndrome was a useful clue to geneticists searching for the mutation that causes the disorder.
African Americans with HIV infection are less likely to be on antiretroviral therapy, less likely to receive prophylaxis for Pneumocystis pneumonia, and less likely to be receiving protease inhibitors than other persons with HIV.
Immunodeficient individuals are at higher risk for infection with Pneumocystis carinii and are frequently put on a regular preventive drug regimen of trimethoprim sulfa and/or inhaled pentamidine to avoid pneumocystis pneumonia.
As early as three months of age, however, the SCID child begins to suffer from mouth infections (thrush), chronic diarrhea, otitis media, and pulmonary infections, including pneumocystis pneumonia.
Pneumocystis carinii-A parasite transitional between a fungus and protozoan, frequently occurring as aggregate forms existing within rounded cystlike structures.