oligonucleotide Hear it!

oligonucleotide Definition

oligo·nu·cleo·tide (-no̵̅o̅klē ō tīd′, -nyo̵̅o̅-)

noun

a short piece of nucleic acid, usually with less than twenty nucleotides, used in genetic engineering and research

oligonucleotide Usage Examples

Converse of object

use: The reverse transcription reaction was primed using an oligonucleotide specific for the body sequence.

Modifies a noun

  • microarrays: Dr. Jennefer Lindsay was awarded a PhD for the thesis: Identification of genes regulated during neuronal apoptosis using oligonucleotide microarrays.
  • primer: Prime selects oligonucleotide primers for a template DNA sequence.
  • probe: We also employed a series of oligonucleotide probes to detect cells expressing the cytokine transcripts in the same tissue biopsies.
  • synthesis: The first section is arranged alphabetically by subject - from Actinomycetes through Oligonucleotide synthesis to Yeast products - with companies listed under each heading.
  • array: Determining the influence of structure on hybridization using oligonucleotide arrays.
  • sequence: Work is in progress to locate the shortest oligonucleotide sequence sufficient to bind to HupR for use in crystallization studies.

Noun used with modifier

  • antisense: To direct RNase L to an RNA target, 2-5A is attached to an antisense oligonucleotide ( 2-5A antisense ).
  • high-density: Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury.
  • density: Identification of altered gene expression in polymyositis using Affymetrix high density oligonucleotide arrays.