Large nucleated red blood-cells make their appearance.
In the female the gonad is complex as in flatworms, composed of a germary for the formation of the eggs, and a vitellary, much more conspicuous and alone figured (ov), consisting of a definite number of large nucleated cells for the nourishment of the eggs.
If the demand be for the red cells owing to loss from haemorrhage or any of the anaemias, the fatty marrow is rapidly replaced by cellular elements; this is mainly an active proliferation of the nucleated red cells, and gives rise to the erythroblastic type of marrow.
It contains a colourless fluid, with flat, oval, nucleated corpuscles, as a rule colourless, but in some cases tinged with yellow or red haemoglobin.
The use of the term to mean the individualized nucleated mass of living protoplasm, which, whether with or without a limiting membrane, primitively forms the proximate histological element of the body of every organism, dates from the second quarter of the i9th century.