With this statement, which was formally subscribed in the presence of the emperor, the development of the Christological doctrine was completed, but not in a manner to obviate further controversy (see Monophysites and Monothelites).
The cause of his leaving Amid was probably either the great pestilence which broke out there in 534 or the furious persecution directed against the Monophysites by Ephraim (patriarch of Antioch 529-544) and Abraham (bishop of Am id c. 520-541).
When, in the 5th century A.D., owing to theological differences the Syriac-using Christians became divided into Nestorians or East Syrians and Jacobites (Monophysites) or West Syrians, certain differences of pronunciation, chiefly in the vowels, began to develop themselves.
Nevertheless she retained great influence; although involved in the revolt of the Syrian monophysites (453), she was ultimately reconciled to Pulcheria and readmitted into the orthodox church.
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