- pl. -·tecs· or -·tec· a member of an American Indian people living in the Mexican states of Oaxaca, Guerrero, and Puebla
- the Mixtecan language of this people
nounpl. Mixtec, or Mix·tecs
- a. A member of a Mesoamerican Indian people of southern Mexico whose civilization was overthrown by the Aztecs in the 1500s.b. A modern-day descendant of this people.
- Any of the related group of Oto-Manguean languages spoken by this people.
Origin of MixtecSpanish from Nahuatl mixtecatl inhabitant of Mixtecapán, a province of the Aztec empire