a condition ranging from a mild infection to a severe disease, caused by a fungus (Histoplasma capsulatum) which may be inhaled or ingested: infections may occur in the lungs, liver, spleen, central nervous system, etc.
See histoplasmosis in American Heritage Dictionary 4
(hĭsˌtō-plăz-mōˈsĭs)
nounpl.his·to·plas·mo·ses(-sēz)
A disease caused by the inhalation of spores of the fungus Histoplasma capsulatum, most often asymptomatic but occasionally producing acute pneumonia or an influenzalike illness and spreading to other organs and systems in the body.