In the age of discovery the Portuguese and Spaniards became the great disseminators of the cultivation of sugar; the cane was planted in Madeira in 1420; it was carried to San Domingo in 1494; and it spread over the occupied portions of the West Indies and South America early in the 16th century.
The disseminators of malaria are exclusively Anophelinae, but even among these it is only certain species that are dangerous, since the others appear to be incapable of acting as hosts of the parasites.
Its already evil reputation has been increased of late years by the fact that it is one of the chief disseminators of bubonic plague.
Tsetse-flies are of great economic and pathological importance as the disseminators of tsetse-fly disease (nagana) and sleeping sickness.
The Museo Civico contains antiquities discovered during excavations near the town (in 1880-1884) in the Picene necropolis, dating from the 8th-4th centuries B.C. The town is the birthplace of the condottiere Niccolo Mauruzzi, and of the learned Francis Philelphus, one of the first disseminators of classical literature, who was born in 1398.