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cyclophosphamide Definition

cy·clo·phos·pha·mide (sī′klō fäsfə mīd′; sī′klō fäs famīd′, -id′)

noun

a white, crystalline compound, CHClNOP, used in treating certain malignancies, esp. lymphomas

Etymology: cyclo- + phosph(oric) + amide

cyclophosphamide Usage Examples

Converse of object

  • include: Conditioning regimens included cyclophosphamide, cytarabine, and total body irradiation.
  • activate: The aim is to achieve high concentrations of activated cyclophosphamide locally in the tumor while minimizing circulating levels of the drug.
  • give: For active or severe kidney disease the most widely used immunosuppressive is cyclophosphamide given intermittently by injection.
  • use: For very severe disease causing inflammation in the kidneys, lungs or brain then we use cyclophosphamide with high doses of steroids.
  • pulse: Indolent disease / recurrent relapses We currently use pulsed cyclophosphamide for disease that is severe but not critical, or for relapsing disease.
  • receive: However, few patients were treated by current standards, with nearly half receiving single-agent cyclophosphamide or no chemotherapy.

Preposition: in

  • vasculitis: It is often used after a course of cyclophosphamide in severe vasculitis, or at the outset in milder vasculitis or milder SLE.

Adjective modifier

  • intravenous: Over the last 15 years, St Thomas has been pioneering the use of much lower doses of intravenous Cyclophosphamide.

Modifies a noun

  • treatment: In this trial all patients will receive our standard low dose pulse Cyclophosphamide treatment.
  • tablet: On the same day you'll also start a course of cyclophosphamide tablets, which you take every day for two weeks.
  • therapy: Preliminary evidence suggests, but cannot confirm, a protective action of glutathione in the bladders of people on cyclophosphamide therapy.
  • prodrug: In the second part of the trial, the cyclophosphamide prodrug will be gradually escalated to identify a maximum tolerated dose.
  • dose: Mesna ( 20 % of the cyclophosphamide dose ) added to the same bag.

Noun used with modifier

  • drug: Side effects of CMF While the drug cyclophosphamide is being injected you may feel hot and slightly dizzy.
  • high-dose: Predictable and dose-related side effects include weight gain with steroids, reduced white cell counts with high-dose cyclophosphamide and bleeding with too much warfarin.
  • pulse: In this trial all patients will receive our standard low dose pulse Cyclophosphamide treatment.
  • dose: In this trial all patients will receive our standard low dose pulse Cyclophosphamide treatment.
  • chemotherapy: CVP is the chemotherapy drugs cyclophosphamide and vincristine with the steroid prednisolone.