noun pl. Calusa or Ca·lu·sas
- a. A Native American people formerly inhabiting the southwest coast of Florida from Tampa Bay to the Florida Keys. The Calusa were extinct by the mid-18th century.b. A member of this people.
- The extinct language of the Calusa, of unknown linguistic affiliation.
Origin: Calusa, fierce people (sense uncertain); perhaps akin to Choctaw kallo, strong.