Loeb found experimentally that increase of metabolic products in muscle greatly raised its osmotic pressure, and so it would absorb water from a relatively concentrated sodium chloride solution.
Welch produced oedema of the lungs experimentally by increasing the pressure in the pulmonary vessels by ligature of the aorta and its branches, but this raised the blood pressure only about one-tenth of an atmosphere, while in some of Loeb's experiments the osmotic pressure, due to retained metabolic products, was equal to over thirty atmospheres.
418, also, Manual of General Pathology (London, 1898); Loeb, " Certain Activities of the Epithelial Tissue of Skin of Guinea-pig, &c.," Johns Hopkins Hosp. Bull., Balt.
Loeb (Journ.
It was not till 1898, however, that his career as a great railway organizer began with his formation, by the aid of the bankers, Kuhn, Loeb & Co., of a syndicate to acquire the Union Pacific line, which was then in the hands of a receiver and was generally regarded as a hopeless failure.