His marriage in March 1518 was arranged by the pope with Madeleine la Tour d'Auvergne, a royal princess of France, whose daughter was the Catherine de' Medici celebrated in French history.
From 1594 to 1641 the duchy remained vested in the French family of La Tour d'Auvergne, one of whom (Henry, viscount of Turenne and marshal of France) had married in 1591 Charlotte de la Marck, the last of her race.
In 1676 the duke of Crequy seized it in the name of Louis XIV., who in 1678 gave it to Godefroy Marie de La Tour d'Auvergne, whose descendants continued in possession till 1795.