Mainline Definition

mānlīn
mainlined, mainlines, mainlining
verb
To inject (a narcotic drug) directly into a large vein.
Webster's New World
To inject a drug intravenously.
American Heritage
adjective
Having a principal, prominent, or moderate position or status.
Webster's New World

(rail transport) Of or pertaining to the principal route or line of a railway.

Wiktionary

(rail transport) Of or pertaining to a surface railway as distinct from an underground, elevated or light rail one.

Wiktionary
noun
The principal road, course, etc.
Webster's New World

Origin of Mainline

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mainline