The amines also exhibit striking differences: in the aliphatic series these compounds may be directly formed from the alkyl haloids and ammonia, but in the benzene series this reaction is quite impossible unless the haloid atom be weakened by the presence of other substituents, e.g.
Thus in the tri-substitution derivatives six isomers, and no more, are possible when two of the substituents are alike; for instance, six diaminobenzoic acids, C 6 H 3 (NH 2) 2 000H, are known; when all are unlike ten isomers are possible; thus, ten oxytoluic acids, C 6 H 3 -CH 3.
Orientation of Substituent Groups.-The determination of the relative positions of the substituents in a benzene derivative constitutes an important factor in the general investigation of such compounds.
According to Armstrong, anthracene behaves unsymmetrically towards substituents, and hence one lateral ring differs from the other; he represents the molecule as consisting of one centric ring, the remaining medial and lateral ring being ethenoid.
To Jaeger is due the determination of the topic parameters of certain haloid-derivatives, and, while showing that the morphotropic effects closely resemble those occasioned by methyl, he established the important fact that, in general, the crystal form depended upon the orientation of the substituents in the benzene complex.
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