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Spanish Main Definition

Spanish Main

  1. the coastal region of the Americas along the Caribbean Sea; esp., the N coast of South America between the Isthmus of Panama & the mouth of the Orinoco: an earlier usage

  2. later, the Caribbean Sea itself, or that part of it adjacent to the N coast of South America, traveled in the 16th-18th cent. by Spanish merchant ships, which were often harassed by pirates