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- the coastal region of the Americas along the Caribbean Sea; esp., the N coast of South America between the Isthmus of Panama & the mouth of the Orinoco: an earlier usage
- later, the Caribbean Sea itself, or that part of it adjacent to the N coast of South America, traveled in the 16th-18th cent. by Spanish merchant ships, which were often harassed by pirates
- The coastal region of mainland Spanish America in the 1500s and 1600s, especially the region of coast on the Caribbean Sea between the Isthmus of Panama and the mouth of the Orinoco River.
- The section of the Caribbean Sea crossed by Spanish ships in colonial times. English buccaneers often raided these treasure-laden ships.