- Seton, Saint Elizabeth Ann (born Elizabeth Ann Bayley) (1774-1821); Am. Rom. Catholic leader: 1st native-born Am. saint: her day is Jan. 4
- Seton, Ernest Thompson (born Ernest Seton Thompson) 1860-1946; U.S. naturalist, writer, & illustrator, born in England
- (medicine, agriculture) A few silk threads or horsehairs, or a strip of linen or the like, introduced beneath the skin by a knife or needle, so as to form an issue; also, the issue so formed.
From French séton