seaport in SE Cuba, on the Caribbean: pop. 418,000
See Santiago de Cuba in American Heritage Dictionary 4
(də kyo͞oˈbə, dĕ ko͞oˈvä)
A city of southeast Cuba on an inlet of the Caribbean Sea. Founded in 1514, it was a haven for buccaneers and smugglers during its early history. Population: 423,000.