capital of Chile, in the central part
- also São Tia·go An island of southern Cape Verde in the northern Atlantic Ocean. It is the largest island in the group and the site of the capital, Praia.
- The capital and largest city of Chile, in the central part of the country east-southeast of Valparaiso. On a plain in the foothills of the Andes, it was founded in 1541.
- also Santiago de los Ca·bal·le·ros A city of northern Dominican Republic northwest of Santo Domingo. Settled c. 1500, it is a transportation hub in a fertile agricultural region.
- also Santiago de Com·pos·te·la A city of northwest Spain south-southwest of La Coruña. The city grew around a shrine housing the reputed tomb of Saint James the Great (discovered in the ninth century) and has long been a pilgrimage center.