Investigation showed the retroviral vector used to load a gene into bone marrow cells had inadvertently carried its DNA into a known oncogene.
However, we have now extended these studies to use retroviral gene transfer methods to stably transduce macrophage precursors with these DNA constructs.
Transgenic mice produced by retroviral transduction of male germ-line stem cells.
Retroviral vectors are the most widely used viral vectors in clinical trials at present.
Practically all retroviral vectors are derived from pathogenic viruses.