Diabetus. Ligate pancreatic ducts of dog. Keep dogs alive till acini degenerate leaving Islets. Try to isolate the internal secretion of these to relieve glycosuria.

-Banting, Frederick Grant
  Note scribbled in his journal, 2.00am, 31Oct. This led to the discovery of insulin for the treatment of diabetes, as recorded in Michael Bliss The Discovery of Insulin (1982).